Entry: AT0000059
Browse | SingleProtein
   
     
 
 Basic Information
Toxin ID 
 AT0000059
Protein ID  
  P59891
Primary acc 
BCTX1_BABCE
Taxon ID 
 244728
Source 
  UniProt
Description 
 Babycurus-toxin 1 (BcTx1) (Fragment).
Ref_source 
Scorpion toxin database,D000626;
 ATDB annotations
Entry List 
TO term type
Description
Category 
TX:0000010,[Category],Neurotoxin,IC:UniProt
TX:0000616,[Category],L-4CC-Sodium channel inhibitor,IC:UniProt
Pathogenesis 
TX:0000248,[Pathogenesis],Nav block,IC:UniProt
Target 
TX:0000132,[Target],Voltage-gated sodium channel,IC:UniProt
Image of protein features
Desulfide infor 
C(4X)C(7X)C(3X)C);
 
 Reciprocity with Channel
Network
  Interaction network of channel (ID: AT0000059)
    The network map have been created accord with the reference paperes of protein which name is P59891(UniProt) . The toxin can effect 146 channels which belong to some special animals,if you want to get more detail informaction please click here or click the network photo.
 Reference Information
References 

Reference [1]
RP:PROTEIN SEQUENCE AND FUNCTION.
RC:TISSUE=Venom;
RX:MEDLINE=97391198; PubMed=9248005; DOI=10.1016/S0041-0101(96)00221-8;
RT:Action of babycurus-toxin 1 from the east African scorpion Babycurus centrurimorphus on the isolated cockroach giant axon.;
RA:Ben Khalifa R. Stankiewicz M. Pelhate M. Serrano-Hernandez S.E. Possani L.D. Hinkel H. Mebs D.;
RL:Toxicon 35:1069-1080(1997).

Keyword 
Direct protein sequencing; Ionic channel inhibitor; Neurotoxin;Secreted; Sodium channel inhibitor; Toxin.
Similarity 
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family.
Spec type 
Babycurus centrurimorphus (East African scorpion).
Tissue 
Expressed by the venom gland.
 Protein Function
Function 
FUNCTION: Binds to sodium channels and inhibits both the activation and inactivation of the activated channels thereby blocking neuronal transmission.
SUBCELLULAR LOCATION: Secreted.
 Pfam annotation
Pfam 
 
 Protein sequence information
Length/MW 
30/3248
Feature 
CHAIN,1,>30,Babycurus-toxin 1. /FTId=PRO_0000066727.
NON_TER,30,30
Sequence 
LKDGYPTNSK  GCKISGCLPG  ENKFCLNECQ   

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