Entry: AT0003500
Browse | SingleProtein
   
     
 
 Basic Information
Toxin ID 
 AT0003500
Protein ID  
  P0C5J7
Primary acc 
SCXT_PARLS
Taxon ID 
 470425
Source 
  UniProt
Description 
 Insect toxin PlIT (Fragment).
 ATDB annotations
Entry List 
TO term type
Description
Category 
TX:0000616,[Category],L-4CC-Sodium channel inhibitor,IDA:PubMed 17618664
Pathogenesis 
TX:0000720,[Pathogenesis],Inhibits the inactivation of channels,IDA:PubMed 17618664
Symptom 
TX:0000375,[Symptom],Paralysis,IDA:PubMed 17618664
Target 
TX:0000132,[Target],Voltage-gated sodium channel,IDA:PubMed 17618664
Image of protein features
 Reciprocity with Channel
Network
  Interaction network of channel (ID: AT0003500)
    The network map have been created accord with the reference paperes of protein which name is P0C5J7(UniProt) . The toxin can effect 21 channels which belong to some special animals,if you want to get more detail informaction please click here or click the network photo.
 Reference Information
References 

Reference [1]
RP:PROTEIN SEQUENCE FUNCTION AND MASS SPECTROMETRY.
RC:TISSUE=Venom;
RX:PubMed=17618664; DOI=10.1016/j.toxicon.2007.04.020;
RT:Identification of insect-selective and mammal-selective toxins from Parabuthus leiosoma venom.;
RA:Ochola J.B. Lwande W. Thiongo T. Rogo L. Herrmann R. Schepers E. Bagine R. Mungai P. Ndiege I.O.;
RL:Toxicon 50:449-456(2007).

Keyword 
Direct protein sequencing; Ionic channel inhibitor; Neurotoxin;Secreted; Sodium channel inhibitor; Toxin.
Similarity 
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family.
Spec type 
Parabuthus liosoma (African black tail scorpion) (Parabuthus leiosoma).
Tissue 
Expressed by the venom gland.
 Protein Function
Function 
FUNCTION: Binds to sodium channels and inhibits the inactivation of the activated channels thereby blocking neuronal transmission (By similarity). Causes prolonged contractile paralysis in C.partellus larvae. It also has significant toxic effects on B.fusca larvae but not on mice.
SUBCELLULAR LOCATION: Secreted.
MASS SPECTROMETRY: Mass=6688.5; Method=Electrospray; Range=1-?; Source=PubMed:17618664;
 Pfam annotation
Pfam 
 
 Protein sequence information
Length/MW 
14/1616
Feature 
CHAIN,1,>14,Insect toxin PlIT. /FTId=PRO_0000307897.
NON_TER,14,14
Sequence 
KDGYPVDNAN  CKYE 

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