Entry: AT0003503
Browse | SingleProtein
   
     
 
 Basic Information
Toxin ID 
 AT0003503
Protein ID  
  P0C5I3
Primary acc 
SIX3A_LEIQH
Taxon ID 
 6884
Source 
  UniProt
Description 
 Beta-insect depressant toxin Lqh-dprIT3a precursor.
 ATDB annotations
Entry List 
TO term type
Description
Category 
TX:0000132,[Target],Voltage-gated sodium channel,IC:UniProt
TX:0000615,[Category],L-4CC-Beta toxin,IC:UniProt
Pathogenesis 
TX:0000477,[Pathogenesis],Membrane depolarization,IC:UniProt
Symptom 
TX:0000375,[Symptom],Paralysis,IC:UniProt
Target 
TX:0000132,[Target],Voltage-gated sodium channel,IC:UniProt
Image of protein features
Desulfide infor 
(1-8)(2-5)(3-6)(4-7)
-C(X2-3)C(X4-8)C(X2-3)C(X9-15)C(X4-8)C(X1)C(X9-15)C-
 Reciprocity with Channel
Network
  Interaction network of channel (ID: AT0003503)
    The network map have been created accord with the reference paperes of protein which name is P0C5I3(UniProt) . The toxin can effect 42 channels which belong to some special animals,if you want to get more detail informaction please click here or click the network photo.
 Reference Information
References 

Reference [1]
RP:NUCLEOTIDE SEQUENCE [MRNA] PARTIAL PROTEIN SEQUENCE FUNCTION AND PARALYTIC DOSE.
RC:TISSUE=Venom and Venom gland;
RX:PubMed=15966742; DOI=10.1021/bi050235t;
RT:Genetic polymorphism and expression of a highly potent scorpion depressant toxin enable refinement of the effects on insect Na channels and illuminate the key role of Asn-58.;
RA:Strugatsky D. Zilberberg N. Stankiewicz M. Ilan N. Turkov M. Cohen L. Pelhate M. Gilles N. Gordon D. Gurevitz M.;
RL:Biochemistry 44:9179-9187(2005).

Keyword 
Amidation; Direct protein sequencing; Ionic channel inhibitor;Neurotoxin; Secreted; Signal; Sodium channel inhibitor; Toxin.
Similarity 
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.
Spec type 
Leiurus quinquestriatus hebraeus (Yellow scorpion).
Tissue 
Expressed by the venom gland.
 Protein Function
Function 
FUNCTION: Depressant insect beta-toxins cause a transient contraction paralysis followed by a slow flaccid paralysis. They bind voltage-independently at site-4 of sodium channels and block action potentials primarily by depolarizing the axonal membrane and suppressing the sodium current. This depressant toxin is active only on insects. It is found in a relatively small amount in the venom and its activity on insects is 10-fold higher compared to other known depressant toxins.
SUBCELLULAR LOCATION: Secreted.
TOXIC DOSE: PD(50) is 3-5 ng/100 mg of body weight of Sarcophaga larvae for both contraction and flaccid paralysis.
 Pfam annotation
Pfam 
 
 Protein sequence information
Length/MW 
85/9217
Feature 
SIGNAL,1,21
CHAIN,22,82,Beta-insect depressant toxin Lqh-dprIT3a. /FTId=PRO_0000307611.
SITE,79,79,Important for toxicity.
MOD_RES,82,82,Glycine amide (By similarity).
DISULFID,31,81,By similarity.
DISULFID,35,56,By similarity.
DISULFID,42,63,By similarity.
DISULFID,46,65,By similarity.
Sequence 
MKLLLLLTIS  ASMLIEGLVN  ADGYIRGGDG  CKVSCVINHV  FCDNECKAAG  GSYGYCWAWG  LACWCEGLPA  DREWDYETNT  CGGKK 

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